Publications

2023023

 

Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration.

Sundaram VK, Schütza V, Schröter NH, Backhaus A, Bilsing A, Joneck L, Seelbach A, Mutschler C, Gomez-Sanchez JA, Schäffner E, Sánchez EE, Akkermann D, Paul C, Schwagarus N, Müller S, Odle A, Childs G, Ewers D, Kungl T, Sitte M, Salinas G, Sereda MW, Nave KA, Schwab MH, Ost M, Arthur-Farraj P, Stassart RM#, Fledrich R#.
Cell Metabolism. 2023 Dec 5;35(12):2136-2152.e9. doi: 10.1016/j.cmet.2023.10.017

 

Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease.

Schäffner E*, Bosch-Queralt M*, Edgar JM, Lehning M, Strauß J, Fleischer N, Kungl T, Wieghofer P, Berghoff SA, Reinert T, Krueger M, Morawski M, Möbius W, Barrantes-Freer A, Stieler J, Sun T, Saher G, Schwab MH, Wrede C, Frosch M, Prinz M, Reich DS, Flügel A, Stadelmann C, Fledrich R#, Nave KA#, Stassart RM#.

Nature Neuroscience. 2023 Jul;26(7):1218-1228. doi: 10.1038/s41593-023-01366-9

 

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease.

Depp C, Sun T, Sasmita AO, Spieth L, Berghoff SA, Nazarenko T, Overhoff K, Steixner-Kumar AA, Subramanian S, Arinrad S, Ruhwedel T, Möbius W, Göbbels S, Saher G, Werner HB, Damkou A, Zampar S, Wirths O, Thalmann M, Simons M, Saito T, Saido T, Krueger-Burg D, Kawaguchi R, Willem M, Haass C, Geschwind D, Ehrenreich H, Stassart R, Nave KA.
Nature. 2023 Jun;618(7964):349-357. doi: 10.1038/s41586-023-06120-6

 

 

2022

 

Schwann cell functions in peripheral nerve development and repair.

Bosch-Queralt M, Fledrich R*, Stassart RM*.

Neurobiology of Disease. 2023 Jan;176:105952. doi: 10.1016/j.nbd.2022.105952

 

 

Early targeting of endoneurial macrophages alleviates the neuropathy and affects abnormal Schwann cell differentiation in a mouse model of Charcot-Marie-Tooth 1A.

Klein D, Groh J, Yuan X, Berve K, Stassart R, Fledrich R, Martini R.
Glia. 2022 Feb 21. doi: 10.1002/glia.2415

 

 

2021

 

A late systemic and brain metastasis from subcutaneous leiomyosarcoma of the right forearm: a case report and review of the literature.

Dietel E, Nestler U, Nenning H, Eisenlöffel C, Stassart R, Meixensberger J.
J Med Case Rep. 2021 Jan 19;15(1):14. doi: 10.1186/s13256-020-02625-0.

 

2020

 

Axo-glial interaction in the injured PNS.

Stassart RM, Woodhoo A.
Dev Neurobiol. 2020 Jul 6. doi: 10.1002/dneu.22771. Online ahead of print.

 

Neural stem cells restore myelin in a demyelinating model of Pelizaeus-Merzbacher disease.

Gruenenfelder FI, McLaughlin M, Griffiths IR, Garbern J, Thomson G, Kuzman P, Barrie JA, McCulloch ML, Penderis J, Stassart RM, Nave KA, Edgar JM.
Brain. 2020 May 1;143(5):1383-1399. doi: 10.1093/brain/awaa080.

 

Redefining the heterogeneity of peripheral nerve cells in health and autoimmunity.

Wolbert J, Li X, Heming M, Mausberg AK, Akkermann D, Frydrychowicz C, Fledrich R, Groeneweg L, Schulz C, Stettner M, Alonso Gonzalez N, Wiendl H, Stassart RM*, Meyer Zu Hörste G*.

Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9466-9476. doi: 10.1073/pnas.1912139117

 

 

2019

 

Axo-glial interdependence in peripheral nerve development.

Fledrich R*, Kungl T, Nave KA, Stassart RM*.

Development. 2019 Nov 12;146(21). pii: dev151704. doi: 10.1242/dev.151704. Review.

 

Neuregulin-1 type I dependent autoparacrine stimulation of Schwann cells in peripheral neuropathies.

Fledrich R*, Akkermann D*, Abdelaal T, Schütza V, Hermes D,  Schäffner E, Soto-Bernardini MC, Götze T, Klink A, Kusch K, Krueger M, Kungl T, Frydrychowicz C, Möbius W, Brück W, Müller WC, Bechmann I, Sereda MW, Schwab MH,  Nave KA, Stassart RM

Nature Communications. 2019, Apr 1;10(1):1467. doi: 10.1038/s41467-019-09385-6

 

Survival-time dependent increase in neuronal IL-6 and astroglial GFAP expression in fatally injured human brain tissue.

Trautz F, Franke H, Bohnert S, Hammer N, Müller W, Stassart RM, Tse R, Zwirner J, Dreßler J, Ondruschka B.

Sci Rep. 2019 Aug 15;9(1):11771. doi: 10.1038/s41598-019-48145-w.

 

 

2018

 

Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy.

Fledrich R, Abdelaal T, Rasch L, Bansal V, Schütza V, Brügger B, Lüchtenborg C, Prukop T, Stenzel J, Rahman RU, Hermes D, Ewers D, Möbius W, Ruhwedel T, Katona I, Weis J, Klein D, Martini R, Brück W, Müller WC, Bonn S, Bechmann I, Nave KA, Stassart RM* and Sereda MW*

Nat Commun. 2018, Aug 2;9(1):3025. doi: 10.1038/s41467-018-05420-0

 

The Axon-Myelin Unit in Development and Degenerative Disease.

Stassart RM, Möbius W, Nave KA, Edgar JM.

Front Neurosci. 2018 Jul 11;12:467. doi: 10.3389/fnins.2018.00467. eCollection 2018. Review.

 

Novel Mutations in the Asparagine Synthetase Gene (ASNS) Associated With Microcephaly.

Schleinitz D, Seidel A, Stassart RM, Klammt J, Hirrlinger PG, Winkler U, Köhler S, Heiker JT, Schönauer R, Bialek J, Krohn K, Hoffmann K, Kovacs P, Hirrlinger J.

Front Genet. 2018 Jul 13;9:245. doi: 10.3389/fgene.2018.00245. eCollection 2018.

 

2017

 

Dietary cholesterol promotes repair of demyelinated lesions in the adult brain.

Berghoff SA, Gerndt N, Winchenbach J, Stumpf SK, Hosang L, Odoardi F, Ruhwedel T, Böhler C, Barrette B, Stassart RM, Liebetanz D, Dibaj P, Möbius W, Edgar JM, Saher G.

Nat Commun. 2017 Jan 24;8:14241. doi: 10.1038/ncomms14241

 

2016

 

A New Targeted Model of Experimental Autoimmune Encephalomyelitis in the Common Marmoset.

Stassart RM, Helms G, Garea-Rodríguez E, Nessler S, Hayardeny L, Wegner C, Schlumbohm C, Fuchs E, Brück W.

Brain Pathol. 2016 Jul;26(4):452-64. doi: 10.1111/bpa.12292. Epub 2015 Sep 22.

 
2015

Nerve regeneration: Specific metabolic demands?

Stassart RM, Nave KA.

Exp Neurol. 2015 Jul;269:90-2. doi: 10.1016/j.expneurol.2015.04.002. Epub 2015 Apr 9

 

Neuronal ADAM10 Promotes Outgrowth of Small-Caliber Myelinated Axons in the Peripheral Nervous System.

Meyer zu Horste G, Derksen A, Stassart RM, Szepanowski F, Thanos M, Stettner M, Boettcher C, Lehmann HC, Hartung HP, Kieseier BC.

J Neuropathol Exp Neurol. 2015 Nov;74(11):1077-85. doi: 10.1097/NEN.0000000000000253.

 

Curcumin therapy in a Plp1 transgenic mouse model of Pelizaeus-Merzbacher disease.

Epplen DB, Prukop T, Nientiedt T, Albrecht P, Arlt FA, Stassart RM, Kassmann CM, Methner A, Nave KA, Werner HB, Sereda MW.

Ann Clin Transl Neurol. 2015 Aug;2(8):787-96. doi: 10.1002/acn3.219. Epub 2015 Jun 24.

 
2014

Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A.

Fledrich R*, Stassart RM*, Klink A, Rasch LM, Prukop T, Haag L, Czesnik D, Kungl T, Abdelaal TA, Keric N, Stadelmann C, Brück W, Nave KA, Sereda MW.

Nat Med. 2014 Sep;20(9):1055-61. doi: 10.1038/nm.3664. Epub 2014 Aug 24.

 

Progesterone antagonist therapy in a Pelizaeus-Merzbacher mouse model.

Prukop T, Epplen DB, Nientiedt T, Wichert SP, Fledrich R, Stassart RM, Rossner MJ, Edgar JM, Werner HB, Nave KA, Sereda MW.

Am J Hum Genet. 2014 Apr 3;94(4):533-46. doi: 10.1016/j.ajhg.2014.03.001. Epub 2014 Mar 27

 

2013

 

A role for Schwann cell-derived neuregulin-1 in remyelination.

Stassart RM*, Fledrich R*, Velanac V, Brinkmann BG, Schwab MH, Meijer D, Sereda MW, Nave KA.

Nat Neurosci. 2013 Jan;16(1):48-54. doi: 10.1038/nn.3281. Epub 2012 Dec 9.

 

2012

 

Murine therapeutic models for Charcot-Marie-Tooth (CMT) disease.

Fledrich R, Stassart RM, Sereda MW.

Br Med Bull. 2012 Jun;102:89-113. doi: 10.1093/bmb/lds010. Epub 2012 May 2. Review.

 

Lithium enhances remyelination of peripheral nerves.

Makoukji J, Belle M, Meffre D, Stassart RM, Grenier J, Shackleford G, Fledrich R, Fonte C, Branchu J, Goulard M, de Waele C, Charbonnier F, Sereda MW, Baulieu EE, Schumacher M, Bernard S, Massaad C.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3973-8. doi: 10.1073/pnas.1121367109. Epub 2012 Feb 21.

 

A rat model of Charcot-Marie-Tooth disease 1A recapitulates disease variability and supplies biomarkers of axonal loss in patients.

Fledrich R, Schlotter-Weigel B, Schnizer TJ, Wichert SP, Stassart RM, Meyer zu Hörste G, Klink A, Weiss BG, Haag U, Walter MC, Rautenstrauss B, Paulus W, Rossner MJ, Sereda MW.

Brain. 2012 Jan;135(Pt 1):72-87. doi: 10.1093/brain/awr322. Epub 2011 Dec 20.

 

2011

 

The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration.

Meyer zu Horste G, Miesbach TA, Muller JI, Fledrich R, Stassart RM, Kieseier BC, Coleman MP, Sereda MW.

Neurobiol Dis. 2011 Apr;42(1):1-8. doi: 10.1016/j.nbd.2010.12.006. Epub 2010 Dec 16.

 
2009
Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models.

Leal A, Huehne K, Bauer F, Sticht H, Berger P, Suter U, Morera B, Del Valle G, Lupski JR, Ekici A, Pasutto F, Endele S, Barrantes R, Berghoff C, Berghoff M, Neundörfer B, Heuss D, Dorn T, Young P, Santolin L, Uhlmann T, Meisterernst M, Sereda MW, Stassart RM, Zu Horste GM, Nave KA, Reis A, Rautenstrauss B.

Neurogenetics. 2009 Oct;10(4):375-376
 
2008
Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.

Brinkmann BG, Agarwal A, Sereda MW, Garratt AN, Müller T, Wende H, Stassart RM, Nawaz S, Humml C, Velanac V, Radyushkin K, Goebbels S, Fischer TM, Franklin RJ, Lai C, Ehrenreich H, Birchmeier C, Schwab MH, Nave KA.

Neuron. 2008 Aug 28;59(4):581-95. doi: 10.1016/j.neuron.2008.06.028.